Our primary collaborations with the labs are related to verification and validation (V&V). The Center is actively participating in the V&V working group led by Jamileh Soudah (DOE HQ) and Dan Meiron (CalTech). T. Plewa is the Chicago's POC with T. Dupont regularly participating in the V&V activities. Initial validation interactions (A. Calder. B. Fryxell) with the labs have been related to the so-called alpha-group inititative, led by Guy Dimonte (LLNL), concerned with development and growth of the Rayleigh-Taylor instability. The results has been recently presented by Dimonte et al. (2005, Phys. Fluids, 16, 1668) and indicate that numerical hydrocodes consistently underestimate the rate of instability growth as observed in experiment. Primary suspect are the initial conditions that may not be carefully measured experimentally, but there is no clear consensus among former and current participants in this work with other factors (mass diffusion) possibly playing an important role. The early V&V experience and knowledge has been shared with the scientific community through review-type publications. Calder et al. has discussed importance of validation in astrophysics (2002, ApJS, 143, 201) and later in more general context of algorithm development (2004, CiSE, 5, 22). The Center's recent validation work (G. Weirs, T. Plewa, T. Dupont, V. Dwarkadas) has been focused around the shock tube experiment at LANL, also known as a shock-cylinder interaction study. Chris Tomkins and Mark Marr-Lyon are lead LANL researchers in this project with Kathy Prestridge being recently named a leader of this experiment. This work has resulted in a discovery, through integrated full-scale numerical experiment, physics processes substantially modifying evolution of the system. In a result, an appropriate modification of the experimental diagnostic system has been suggested and is considered for building. The results has been presented at the 5th HEDLA meeting, AMR Chicago workshop, and the 9th IWPCTM conference. A refereed journal publication is being prepared. Our future validation work will be focused on a converging shock-tube experiment (P. Dimotakis, CalTech) and high-energy density (laser) experiments. We are also initating a collaboration with Guy Dimonte (LANL) and his group to study the Landau-Darrieus instability. The Center has recognized the need and secure personel required to support these new initiatives. Several candidates has been interviewed and three new postdoctoral associates (A. Haque, N. Hearn, G. Jordan) are joining the Center to work exclusively in the domain of code validation. The Center is also actively participating in several international collaborations providing a platform for algorithm and software development with associated physics applications offering ideal testbed for the FLASH code. The collaborations include a group of astrophysical hydrodynamicists at the University of Palermo, Italy, led by Salvator Orlando who studies a distruptive effects of shock waves, heat conduction and cooling on the evolution of interstellar clouds. The results of this work has been recently submitted to Astron. & Astroph. journal. Erik-Jan Rijkhorst, Univ. Leiden, The Netherlands, has implemented and successfully tested a new highly efficient and scalable ray-tracing algorithm for photoionization calculations. The algorithm has been proposed by T. Plewa with parallel implementation overseen by A. Dubey. No such tool is currently available to astrophysicists. Rijkhorst in collaboration with G. Mellema and V. Icke (both Leiden) and T. Plewa and A. Dubey are applying the new method to study evaporation of molecular clouds and formation and evolution of dense molecular globules. Plans are being made to extend the algorithm towards full radiative transfer. The results of this work are prepared for publication. A MURI proposal to study ablation effects using picosecond lasers has been submitted to the Office of Air Force Office by T. Pollock (PI) and K. Thornton (Co-I), Dept. of Materials Science & Enginneering, UMich, and recently accepted. T. Plewa, A. Calder, and A. Khokhlov will be overseeing potential integration of the IBEAM family of solvers (D. Swesty) with FLASH. T. Plewa is participating in the project led by P. Drake (UMich) to study hydrodynamic instabilities in the high-energy density regime of relevance to astrophysics on the Omega laser. Related to this is the NIF Letter of Interest proposing studying supernova hydrodynamics on this new facility.